HLA Class 3

Question.

209. The HLA class 3 rejection genes are important elements in

1. Transplant rejection phenomenon.

2. Governing susceptibility of autoimmune diseases.

3. Immune surveillance.

4. Antigen presentaion and elimination.

Answer

2. Governing susceptibility of autoimmune diseases.

Reference

Harrison's15^th Edition,Pg-1832 Chapter 306 Chapter 308 Table 308-3

Ananthanarayanan 5^th Edition Page 118

Ananthanarayanan 6^th Edition Page 120,121

Nelson Table 117 -1

Quality

Thinker

Status

New

QTDF

Ananthanarayanan

Discussion

Harrison and Nelson says that the Diseases Common Variable Immunodeficiency and IgA deficiency are mostly due to defects in MHC III. A polymorphism in the promoter of the TNF-a (TNF-alpha) gene in the HLA class III region, which is associated with quantitative variation in the production of TNF, has recently been shown to have an association with the manifestations of a number of infectious diseases, including cerebral malaria, mucocutaneous leishmaniasis, lepromatous leprosy, scarring trachoma, persistent hepatitis B infection, and fatal meningicoccal meningitis

And we can see that derangement in the metabolism of Complement C2 and C4 leads to SLE and other diseases

Explanation

1. Transplant rejection phenomenon involves MHC I and MHC II.

2. Autoimmune diseases like SLE are due to derangement in C2 and C4.

3. Immune surveillance is by MHC I and MHC II.

4. Antigen presentaion and elimination is by MHC II.

Comments

Theme Couple from HLA III

Tips

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